Ecole Normale Superieure Paris-Saclay

RPG-Ecole-Normale

University Paris-Saclay
Website
Elisa Budyn

Problems

Mechanobiology in human tissues.

Approach

Organoids and medicine screening, Material characterization by chemical and mechanical measurements, transcriptomics, multi-modal imaging and cell mirco-environment computational modeling.

Findings

  • E. Budyn, A Bone-on-Chip as a 3D in Vitro Platform to assess the Effect of Stem Cell Age on Tissue Quality and Test Medicines, (European Chapter of the Tissue Engineering and Regenerative Medicine International Society - TERMIS), Tissue Engineering Part A, 29:13-14, 2023
  • B. Singh, M. Essameldin Abdelgawad, Z. Ali, J. Bailey4 E. Budyn, P. Civita, M. J.D. Clift, J. T. Connelly, S.Constant, M. Hittinger, H. Kandarova, V. R. Kearns, T. Kiuru, T. Kostrzewski, S. Kress, V. Marsh Durban, C.- M. Lehr, H. McMillan, J. K. Metz, V. Monteban, D. Movia, C. Neto, C. Owen, L. Paasonen, K. A. Palmer, G. J. Pilkington, K. Pilkington, A. Prina-Mello, C. Roper, J. Sheard, S. Smith., J. E. Turner, I. Roy, M. A. Tutty, E. Velliou and J. M. Wilkinson, Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings, Alternatives to Laboratory Animals May;49(3):93-110. 2021 doi: 10.1177/02611929211025006
  • A. Avgeri, S. Sanders, B. Cinquin, L. Sedel, P. Bizot, E. Budyn, Mechanical properties of scar tissue of hip capsule ligament for different implant materials, JOM, 73, 2377-2389, 2021
  • E. Budyn, N. Gaci, S. Sanders, M. Bensidhoum, E. Schmidt, B. Cinquin, P. Tauc, H. Petite, Human Stem Cells Derived Osteocytes in Bone-on-Chip, MRS Advance, vol. 3(36), p. 1443-1455, (2018)doi.org/10.1557/adv.2018.278
  • S. Bhogle, G. Mistri, S. Lacey, B. Vesper, J. Radosevich, M. Colvard, E. Budyn, Identification of Cell Microenvironment in Porcine Skin Laser Cauterization, CMAME, v. 314, p.19-45, 2017. DOI:10.1016/j.cma.2016.10.018
  • 10. M. Curtis, E. Budyn, T. Desai, A. M. Samarel and B. Russell, “Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction via RhoA/ROCK and KPC signaling”, Biomechanics and Modeling in Mechanobiology, 12(1):95-109, 2013. DOI10.1007/s10237-012-0384-9.
  • 11. J. Jonvaux, T. Hoc and E. Budyn, “Analysis of micro fracture in human Haversian cortical bone under compression”, International Journal in Numerical Methods in Biomedical Engineering, 28(9):974-998, 2012. DOI: 10.1002/cnm.2478

Impact

Human tissue characterization of bone, intervertebral disk, skin, heart and ligament.

Core Competencies

Computational mechanics, mechanics of materials, fracture, mechanobiology, biomechanics, biological imaging, cell and tissue culture.

Funding Agencies

French CNRS and SOLEIL synchrotron.

Committee

  • Vice-Chair of the Biomechanics Technical Committee of EMI Engineering Mechanics Institute (ASCE American Society of Civil Engineers) (October 2023-2025).
  • Member of the Computational Mechanics Technical Committee of EMI Engineering Mechanics Institute (ASCE American Society of Civil Engineers) (2006-present)
  • Member of the USACM Novel Methods in Computational Engineering and Sciences (TTA) 2019- present https://unsacm.memberclicks.net/novelmethodsmembers
  • Member of the USACM Biological Systems Technical Thrust Area (TTA) 2015-present.